Mastering biotechnologies and therapeutic innovations

Level 2 -

Mastering ADCs: From design to clinical success

Presentation

Why participate?

Know the major stages of the development cycle of an Antibody-Drug Conjugate (ADC). Understand the tools available to modulate ADC activity.

Training Context:

The ADC field is booming, with $100 billion in transactions recorded in 2023. As of March 2024, 13 ADCs were approved exclusively in oncology across 24 therapeutic indications. Worldwide, over 800 products are currently in research and development, with more than 250 in clinical trials.

Learning objectives

  • Understand the structure and mechanism of action of ADCs
  • Discover the ADC market
  • Understand the avenues for improving ADCs
  • Gain insight into essential tools for managing R&D projects involving ADCs
  • Understand the licensing challenges related to ADCs

Content

Welcome of participants, introductions

  • CHARACTERISTICS OF ADCs
    • Structure of ADCs
    • Mechanism of action of ADCs
    • Key components of an ADC: Antibody – Linker – Cytotoxic payloads
  • THE ADC MARKET
    • Therapeutic indications
    • A growing field: Biotech and Pharma
    • Global market
    • Panel of ADC targets
    • ADCs in preclinical and clinical development
  • MAIN CHALLENGES OF ADCs
    • Adverse events
    • Resistance to ADCs
    • Overcoming ADC resistance
    • Strategies for ADC optimization
    • Bispecific ADCs
    • Therapeutic combinations: chemotherapy, immune checkpoint inhibitors (ICI)…
  • ROADMAP FOR DESIGNING ADCs
    • TPP (Target Product Profile)
    • Target selection – criteria
    • Key experiments
    • Gantt chart
  • ADC SUCCESS STORIES
    • ADC product licensing
    • ADC technology licensing

General discussion, conclusion, and evaluation

Teaching methods

Interactive Teaching, Case Studies, Experience Sharing

Audience

Business developer, Application engineer, Research engineer, Researcher, Manager from service companies or Biotechnology firms

Prerequisites

Good knowledge of antibodies or having completed the training “Fundamentals of therapeutic antibodies”

Duration

Half-day, 3.5 hours

Price

375 € HT (Public)
300 € HT (Membre)
150 € HT (Académique)

Prices: Excluding tax, as the training is not subject to VAT.
In-house training rate: Please contact us.

Trainers

Catalogue de formations-MabDesign-2023.pdf (3)

Claudine

VERMOT-DESROCHES

Expert consultant in immunotherapies & CEO
TheraWings Consulting

Rating

There is no rating available because this training session was never carried out.

The benefits of our courses

  • Personalized support
  • Skills assessment
  • Certificate of completion
  • Training quality evaluation
  • Accessible to people with disabilities (please contact us)

How to access and deadlines

Registering online or by e-mail is a pre-registration. We will process your request within one week:

  • Contact by e-mail or telephone
  • Sending of administrative and educational documents: training agreement, training programme and positioning questionnaire.

Signing the training agreement commits the company or individual to the training course. Cancellation conditions are specified in the training agreement.

When no session date is specified, pre-registration allows us to note your interest in a programme, and we will keep you informed as soon as a new session is organised.

For more information, contact Daphné Brisard: 02 47 36 63 18 or formation@mabdesign.fr

Jean-Roch Fabreguettes

MEARY

Directeur Médical et Personne Responsable du Centre MEARY de thérapie cellulaire et génique au sein de l’hôpital Saint-Louis à Paris

Jean-Roch Fabreguettes est un spécialiste de la recherche translationnelle et des phases précoces de développement clinique des médicaments de thérapie innovantes (MTI). Pharmacien, titulaire d’un doctorat de l’Université de Montpellier 1, il a travaillé plus de 25 ans dans le domaine et a contribué, pour des équipes académiques comme pour des start-ups, à la réalisation de plus de 30 programmes de recherche sur différents types de MTI : thérapie génique in vivo ou ex vivo, thérapie cellulaire, ingénierie tissulaire… Il est actuellement Directeur Médical et Personne Responsable du Centre MEARY de thérapie cellulaire et génique au sein de l’hôpital Saint-Louis à Paris. Le centre MEARY est une plateforme de l’Assistance Publique – Hôpitaux de Paris (AP-HP), dédiée à la fabrication de médicament de thérapie innovante expérimentaux. Laboratoire membre de l’ISCT, il est autorisé par l’ANSM et dispose d’un certificat GMP. A ce titre Jean-Roch Fabreguettes est impliqué dans le développement clinique et la fabrication de nombreux MTI : CAR-T cells, lymphocytes T régulateurs, cellules stromales mésenchymateuses…

Précédemment, Jean-Roch Fabreguettes a été expert Qualité (CMC) auprès de l’ANSM durant 9 ans et a conseillé différentes sociétés de biotechnologies. Il est un intervenant régulier pour l’Université Paris Cité et un membre actif de l’ISCT et de réseaux nationaux et internationaux sur les MTI (UNI-TC, Join4ATMP).