Mastering biotechnologies and therapeutic innovations

Level 1 -

mRNA and Their Therapeutic Applications

Presentation

Why participate?

Gain mastery of mRNA therapeutic applications - from bioproduction to clinical use - and understand their revolutionary role in medicine, particularly in vaccination and gene therapy

Training Context:

Since the emergence of nucleic acid molecules, DNA and RNA have drawn increasing attention due to their essential roles in cellular function. Traditionally, DNA is considered the carrier of genetic information, while RNA plays a key role in protein synthesis. The discovery of non-coding RNAs, such as microRNAs, has highlighted their importance in gene regulation, positioning RNAs as promising targets for novel therapies. For instance, mRNAs are now used in cancer vaccines, and technologies like nanoparticles enable targeted delivery and increased stability of these molecules.
This training focuses on current advances in mRNA-based therapies and addresses the ongoing challenges in their development.

Learning objectives

  • Understand the mechanisms of action of therapeutic mRNA
  • Learn about the development and delivery challenges of therapeutic mRNA
  • Advocate internally for the advantages of mRNA as a therapeutic modality
  • Understand the clinical implications of therapeutic mRNA

Content

Welcome and participant introductions

Introduction

  • Overview of mRNA

  • Protein synthesis from mRNA

  • Market data

  • Therapeutic uses of mRNA

Vaccination (prophylactic and therapeutic)

  • Mechanisms of action of vaccination

Therapeutic mRNA

  • Mechanisms of action of therapeutic mRNA

Bioproduction of synthetic mRNA

  • From mRNA design to bioproduction

  • Challenges related to bioproduction

Clinical applications

General discussion, conclusion, and evaluation

Teaching methods

Interactive Teaching, Case Studies, Experience Sharing

Audience

Any scientific professional with a strong background in biology and an interest in mRNA-related topics

Prerequisites

Strong knowledge of biology, molecular biology, and DNA structure required

Duration

1 day, 7 hours

Price

750 € HT (Public)
600 € HT (Membre)
300 € HT (Académique)

Prices: Excluding tax, as the training is not subject to VAT.
In-house training rate: Please contact us.

Rating

There is no rating available because this training session was never carried out.

The benefits of our courses

  • Personalized support
  • Skills assessment
  • Certificate of completion
  • Training quality evaluation
  • Accessible to people with disabilities (please contact us)

How to access and deadlines

Registering online or by e-mail is a pre-registration. We will process your request within one week:

  • Contact by e-mail or telephone
  • Sending of administrative and educational documents: training agreement, training programme and positioning questionnaire.

Signing the training agreement commits the company or individual to the training course. Cancellation conditions are specified in the training agreement.

When no session date is specified, pre-registration allows us to note your interest in a programme, and we will keep you informed as soon as a new session is organised.

For more information, contact Daphné Brisard: 02 47 36 63 18 or formation@mabdesign.fr

Jean-Roch Fabreguettes

MEARY

Directeur Médical et Personne Responsable du Centre MEARY de thérapie cellulaire et génique au sein de l’hôpital Saint-Louis à Paris

Jean-Roch Fabreguettes est un spécialiste de la recherche translationnelle et des phases précoces de développement clinique des médicaments de thérapie innovantes (MTI). Pharmacien, titulaire d’un doctorat de l’Université de Montpellier 1, il a travaillé plus de 25 ans dans le domaine et a contribué, pour des équipes académiques comme pour des start-ups, à la réalisation de plus de 30 programmes de recherche sur différents types de MTI : thérapie génique in vivo ou ex vivo, thérapie cellulaire, ingénierie tissulaire… Il est actuellement Directeur Médical et Personne Responsable du Centre MEARY de thérapie cellulaire et génique au sein de l’hôpital Saint-Louis à Paris. Le centre MEARY est une plateforme de l’Assistance Publique – Hôpitaux de Paris (AP-HP), dédiée à la fabrication de médicament de thérapie innovante expérimentaux. Laboratoire membre de l’ISCT, il est autorisé par l’ANSM et dispose d’un certificat GMP. A ce titre Jean-Roch Fabreguettes est impliqué dans le développement clinique et la fabrication de nombreux MTI : CAR-T cells, lymphocytes T régulateurs, cellules stromales mésenchymateuses…

Précédemment, Jean-Roch Fabreguettes a été expert Qualité (CMC) auprès de l’ANSM durant 9 ans et a conseillé différentes sociétés de biotechnologies. Il est un intervenant régulier pour l’Université Paris Cité et un membre actif de l’ISCT et de réseaux nationaux et internationaux sur les MTI (UNI-TC, Join4ATMP).