{"id":36458,"date":"2025-11-12T10:00:00","date_gmt":"2025-11-12T09:00:00","guid":{"rendered":"https:\/\/mabdesign.fr\/?p=36458"},"modified":"2025-11-18T12:14:14","modified_gmt":"2025-11-18T11:14:14","slug":"experts-corner-gene-therapies","status":"publish","type":"post","link":"https:\/\/mabdesign.fr\/en\/experts-corner-gene-therapies\/","title":{"rendered":"Experts\u2019 corner : Gene Therapies"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"36458\" class=\"elementor elementor-36458 elementor-36149\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-70ba9a4 e-flex e-con-boxed e-con e-parent\" data-id=\"70ba9a4\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-21ac03f elementor-widget elementor-widget-text-editor\" data-id=\"21ac03f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>With &#8220;The Experts Corner,&#8221; MabDesign offers a deep dive into the heart of innovation in biotherapies. Through exclusive interviews with industry experts, discover their market vision, their analyses of current challenges, and their perspectives on the latest advances. These inspiring conversations will help you better understand the present and future of biomanufacturing and <span data-teams=\"true\">biopharmaceuticals<\/span>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bb69397 e-flex e-con-boxed e-con e-parent\" data-id=\"bb69397\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0f10725 e-con-full e-flex e-con e-child\" data-id=\"0f10725\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6ba549e elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"6ba549e\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"968\" src=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/10\/IMG_2327-846x1024.jpeg\" class=\"attachment-large size-large wp-image-36163\" alt=\"\" srcset=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/10\/IMG_2327-846x1024.jpeg 846w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/10\/IMG_2327-248x300.jpeg 248w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/10\/IMG_2327-768x929.jpeg 768w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/10\/IMG_2327-1269x1536.jpeg 1269w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/10\/IMG_2327-1692x2048.jpeg 1692w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1285290 e-con-full e-flex e-con e-child\" data-id=\"1285290\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c1f29b9 elementor-widget elementor-widget-heading\" data-id=\"c1f29b9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Gene Therapies<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-185c31b e-con-full e-flex e-con e-child\" data-id=\"185c31b\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ff9880c elementor-widget elementor-widget-heading\" data-id=\"ff9880c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Samuel Salot<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-95226ce elementor-widget elementor-widget-heading\" data-id=\"95226ce\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Director Of Operations, EG427<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbd1a3a e-con-full e-flex e-con e-child\" data-id=\"bbd1a3a\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-431b3cd elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"431b3cd\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-quote-left\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M464 256h-80v-64c0-35.3 28.7-64 64-64h8c13.3 0 24-10.7 24-24V56c0-13.3-10.7-24-24-24h-8c-88.4 0-160 71.6-160 160v240c0 26.5 21.5 48 48 48h128c26.5 0 48-21.5 48-48V304c0-26.5-21.5-48-48-48zm-288 0H96v-64c0-35.3 28.7-64 64-64h8c13.3 0 24-10.7 24-24V56c0-13.3-10.7-24-24-24h-8C71.6 32 0 103.6 0 192v240c0 26.5 21.5 48 48 48h128c26.5 0 48-21.5 48-48V304c0-26.5-21.5-48-48-48z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3dd7198 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"3dd7198\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Technologies are becoming increasingly sophisticated, but also more targeted and adaptable. It\u2019s reminiscent of antibodies in the 1990s: we are entering a phase of accelerated maturation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b4eba7b elementor-widget__width-initial elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"b4eba7b\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-quote-right\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M464 32H336c-26.5 0-48 21.5-48 48v128c0 26.5 21.5 48 48 48h80v64c0 35.3-28.7 64-64 64h-8c-13.3 0-24 10.7-24 24v48c0 13.3 10.7 24 24 24h8c88.4 0 160-71.6 160-160V80c0-26.5-21.5-48-48-48zm-288 0H48C21.5 32 0 53.5 0 80v128c0 26.5 21.5 48 48 48h80v64c0 35.3-28.7 64-64 64h-8c-13.3 0-24 10.7-24 24v48c0 13.3 10.7 24 24 24h8c88.4 0 160-71.6 160-160V80c0-26.5-21.5-48-48-48z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-34244d1 e-flex e-con-boxed e-con e-parent\" data-id=\"34244d1\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e6b8003 e-con-full e-flex e-con e-child\" data-id=\"e6b8003\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e2e2618 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"e2e2618\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"356\" height=\"141\" src=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/10\/telechargement.png\" class=\"attachment-1536x1536 size-1536x1536 wp-image-36161\" alt=\"\" srcset=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/10\/telechargement.png 356w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/10\/telechargement-300x119.png 300w\" sizes=\"(max-width: 356px) 100vw, 356px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7ffca97 e-con-full e-flex e-con e-child\" data-id=\"7ffca97\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-256af04 elementor-widget elementor-widget-text-editor\" data-id=\"256af04\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>EG 427 is a French biotech founded in 2019, with a DNA therapy approach that we define as targeted. Unlike other systemic approaches, our technology relies on a non-replicative herpes vector, allowing extremely precise targeting of specific neurons. Once inside, it can express transgenes in a stable, selective, and long-lasting way \u2014 opening the door to durable therapeutic effects.<\/p><p>Our first developments focus on indications linked to the peripheral nervous system, but the platform has a much broader potential, notably thanks to its ability to integrate large transgenes and to leverage the natural latency of HSV. This allows fine regulation of therapeutic transgene expression, including for complex applications.<\/p><p>Today, we have an active clinical program: in June 2024, the FDA authorized us to launch a trial in neurogenic bladder, a common condition with significant unmet patient needs. This demonstrates both the medical relevance and the maturity of our technology.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0fec223 e-flex e-con-boxed e-con e-parent\" data-id=\"0fec223\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2c0b365 elementor-widget elementor-widget-text-editor\" data-id=\"2c0b365\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>You are currently COO of EG 427. Could you tell us about your background before joining the company, and explain your current role?<\/strong><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b242629 elementor-widget elementor-widget-text-editor\" data-id=\"b242629\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>I started my career at Innate Pharma, where I was trained in the fundamentals of biopharmaceutical development. My very first project was in cell therapy, which quickly led me to explore gene transfer and immunotherapy. I then co-founded a service company specializing in immuno-monitoring, a spin-off from Innate, before moving into strategic consulting for French biotechs. There, I supported projects on CAR-T, monoclonal antibodies and derivatives, as well as therapeutic vaccines, often linked to development or corporate structuring challenges.<\/p><p>It was during this period that I met Philippe Chambon, CEO of EG 427. He had just returned from the United States with the ambition to develop this innovative viral technology. He offered me the opportunity to help him build the company from scratch. Together, we set up the infrastructure, recruited the first teams, laid the foundations of the development plan, and most importantly, worked on bioproduction processes.<br \/>My role has evolved with the company\u2019s growth, and I am now heavily involved in strategic, industrial, and regulatory aspects, particularly around our lead asset, EG110A.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b41be0d e-flex e-con-boxed e-con e-parent\" data-id=\"b41be0d\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-81de370 elementor-widget elementor-widget-text-editor\" data-id=\"81de370\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>You mentioned that you started working in gene therapy very early. How have you seen the field evolve, particularly in terms of major technological advances?<\/strong><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2460c79 e-flex e-con-boxed e-con e-parent\" data-id=\"2460c79\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-587cae2 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"587cae2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>&#8220;The arrival of CAR-T, driven by figures such as Carl June and Michel Sadelain, marked a real paradigm shift.&#8221;<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9eac3b elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"e9eac3b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>When I started, cell therapy was still experimental. Expectations were high, but so were the limitations: lack of standardization, high costs, limited reproducibility. The arrival of CAR-T, driven by figures such as Carl June and Michel Sadelain, marked a real paradigm shift. The launch of <em>Kymriah<\/em> was a strong signal for the industry.<br \/>At the same time, tangible results began to emerge in \u201cpure\u201d gene therapy, with vectors such as AAV, particularly in rare diseases like Duchenne muscular dystrophy. But the field remains cyclical. Before COVID, annual investments reached around $25 billion, only to face a steep drop after the crisis. That said, innovation never stopped. The recent acquisition of Capstan Therapeutics by AbbVie \u2014 to develop in vivo CAR-T using non-viral vectors \u2014 illustrates how simpler, more industrializable models are emerging.<br \/>Technologies are becoming increasingly sophisticated, but also more targeted and adaptable. It\u2019s reminiscent of antibodies in the 1990s: we are entering a phase of accelerated maturation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d50c4c4 e-flex e-con-boxed e-con e-parent\" data-id=\"d50c4c4\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ad30eb0 e-flex e-con-boxed e-con e-parent\" data-id=\"ad30eb0\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-505aec2 elementor-widget elementor-widget-text-editor\" data-id=\"505aec2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>Monoclonal antibodies are now a mature field, unlike newer approaches such as gene or cell therapies. Do you see fundamental differences in terms of developability, business model, or industrial trajectory?<\/strong><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0e4dd0a e-flex e-con-boxed e-con e-parent\" data-id=\"0e4dd0a\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec2c1a elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"8ec2c1a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>&#8220;Our processes are close to those of vaccine production: proven, easy to scale industrially.&#8221;<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5636996 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"5636996\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Absolutely. Autologous therapies make sense scientifically, but they raise major issues in terms of logistics, standardization, and reimbursement. Their industrialization remains challenging. Allogeneic approaches, though promising, still face biological hurdles \u2014 compatibility, rejection, expansion.<\/p><p>In contrast, vectorized gene therapies, such as AAV, have the potential to reach broader populations \u2014 provided that manufacturing costs are reduced and processes optimized.<br \/>This is where our non-replicative HSV approach is highly relevant. Our processes are close to those of vaccine production: proven, easy to scale industrially. The vector quantities required per dose are low, which means production costs are significantly lower than for AAV. This model enables us to envision broader applications, particularly for high-prevalence chronic diseases.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f21294f e-flex e-con-boxed e-con e-parent\" data-id=\"f21294f\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5a0dedf elementor-widget elementor-widget-text-editor\" data-id=\"5a0dedf\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>You have now entered the clinical stage with your product. What do you see as the main translational challenges in moving from preclinical to Phase I?<\/strong><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-737d771 e-con-full e-flex e-con e-parent\" data-id=\"737d771\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6635ec1 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"6635ec1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>&#8220;Preclinical is the stage where you lay the foundations \u2014 and those foundations must be solid.&#8221;<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-77a721a elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"77a721a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A key point was integrating regulatory considerations from the start. As early as 2021, we structured our development plan with FDA expectations in mind, and engaged in dialogue with them very early on. This allowed us to perform useful gap analyses and adjust our priorities accordingly.<\/p><p>Scientifically, the challenge is to turn an innovative idea into robust preclinical data. Often, the tools don\u2019t yet exist: you need to design or adapt specific assays, avoid generating unusable data, and stay focused on what matters \u2014 efficacy and safety.<br \/>This work requires constant agility, because new obstacles arise every week. Preclinical is the stage where you lay the foundations \u2014 and those foundations must be solid.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-09f6ba3 e-flex e-con-boxed e-con e-parent\" data-id=\"09f6ba3\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ca5ab23 elementor-widget elementor-widget-text-editor\" data-id=\"ca5ab23\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><p><strong>You are working on an innovative therapy. How do you manage relationships with regulatory agencies?<\/strong><\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bcad6c6 e-flex e-con-boxed e-con e-parent\" data-id=\"bcad6c6\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-57f6a9d elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"57f6a9d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>&#8220;Demonstrate efficacy, ensure safety, and understand the mechanism of action.&#8221;<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30a5e5f elementor-widget elementor-widget-text-editor\" data-id=\"30a5e5f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We chose to engage with the authorities very early, even at a stage when some elements were not yet fully established. In the United States, interactions with the FDA were particularly constructive. They helped us refine our hypotheses and build a clear plan.<br \/>In parallel, we built a network of top-level experts \u2014 in CMC, analytics, pharmacology. These are highly experienced people who work with us continuously, not just on an ad-hoc basis.<\/p><p>This approach allowed us to make every development decision with regulatory requirements in mind, which I believe is essential for innovative projects. We have always sought to focus on what matters: demonstrate efficacy, ensure safety, and understand the mechanism of action.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9cae32b e-flex e-con-boxed e-con e-parent\" data-id=\"9cae32b\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ebb93bb elementor-widget elementor-widget-text-editor\" data-id=\"ebb93bb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>In your view, what are the key elements of a strong ecosystem to develop an innovative gene therapy?<\/strong><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3fe0c98 e-flex e-con-boxed e-con e-parent\" data-id=\"3fe0c98\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-448be96 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"448be96\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>&#8220;<\/strong>The success of a program is not just about technology.&#8221;<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cab5050 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"cab5050\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Both internal collaborations, often underestimated, and external partnerships.<br \/>Internally, strong alignment between leadership, investors, and operational teams is critical to ensure project success. It requires transparency, listening, and shared objectives. Internal tensions can hold back even the most innovative projects.<br \/>Externally, the human factor is crucial. Working with competent providers is important \u2014 but working with engaged ones is essential. A good example is our collaboration with our Italian CDMO. We were very present on site because we wanted to understand the issues and move forward together. Shared responsibility must be assumed, even when difficulties arise.<\/p><p>The success of a program is not just about technology. It\u2019s also about human relationships, trust, and mutual commitment.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f4d5861 e-flex e-con-boxed e-con e-parent\" data-id=\"f4d5861\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3bbbce7 elementor-widget elementor-widget-text-editor\" data-id=\"3bbbce7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>You are based in Cochin, with a presence in the United States. In your opinion, what role does the local ecosystem play in developing your gene therapy?<\/strong><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0c249e0 e-con-full e-flex e-con e-child\" data-id=\"0c249e0\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cef82f0 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"cef82f0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>&#8220;We have always had a global vision: we seek expertise wherever it is, whether in Paris, the United States, or elsewhere in Europe.&#8221;<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6bbe636 elementor-widget elementor-widget-text-editor\" data-id=\"6bbe636\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We have always had a global vision: we seek expertise wherever it is, whether in Paris, the United States, or elsewhere in Europe. The local ecosystem is important when it brings value, but we don\u2019t limit ourselves to it.<\/p><p>We faced a specific regulatory constraint in France \u2014 the MOT (Microorganisms and Toxins) regulation \u2014 which heavily restricts certain manipulations involving our transgene, even though it is only a non-toxic fragment of botulinum toxins. These unique French constraints forced us to outsource certain operations abroad, including production in Italy and Germany.<\/p><p>This was not a matter of convenience, but a regulatory necessity. It also highlights the difficulty of developing some innovations within a rigid local framework. Hence the importance of remaining pragmatic and agile in choosing partners and sites.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-227807b e-flex e-con-boxed e-con e-parent\" data-id=\"227807b\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-872be66 elementor-widget elementor-widget-text-editor\" data-id=\"872be66\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><ul><li><strong>How do you view the evolution of the competitive landscape in gene therapy?<\/strong><\/li><\/ul><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d7b526a e-flex e-con-boxed e-con e-parent\" data-id=\"d7b526a\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9350051 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"9350051\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>&#8220;<\/strong>AbbVie\u2019s acquisition of Capstan, with its in vivo CAR-T approach, is a strong signal&#8230;&#8221;<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b9cab30 elementor-widget elementor-widget-text-editor\" data-id=\"b9cab30\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>I don\u2019t see the field as one of direct competition, but rather as a sector under construction, with room for multiple models. AbbVie\u2019s acquisition of Capstan, with its in vivo CAR-T approach, is a strong signal: the shift from costly platforms to more industrializable solutions is underway. This opens the way for the democratization of gene therapy, with potentially curative treatments compatible with large-scale production. At EG 427, this is precisely our ambition: to make DNA therapy accessible, standardized, and economically viable for healthcare systems.<\/p><p>Our technology is built on solid foundations: HSV is well known, minimally immunogenic, and re-administrable. Our ambition is to make these innovations available to the largest number of patients, particularly for high-prevalence chronic diseases.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c7d7e09 e-flex e-con-boxed e-con e-parent\" data-id=\"c7d7e09\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef3f597 elementor-widget elementor-widget-heading\" data-id=\"ef3f597\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Samuel Salot, EG427,  interviewed by the MabDesign team - July 2025\n<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e0efe3b elementor-widget elementor-widget-heading\" data-id=\"e0efe3b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Since this interview, EG427 has issued two press releases announcing clinical results and the receipt of a Fast Track Designation from the U.S. Food and Drug Administration. Their press releases are available here:<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c17f42 elementor-widget elementor-widget-heading\" data-id=\"2c17f42\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/eg427.com\/EG-427-Announces-Compelling-Initial-Topline-Clinical-Results-with-EG110A-DNA-Medicine-in-Neurogenic-Bladder-Patients.html\" target=\"_blank\">Result: https:\/\/eg427.com\/EG-427-Announces-Compelling-Initial-Topline-Clinical-Results-with-EG110A-DNA-Medicine-in-Neurogenic-Bladder-Patients.html<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1406e41 elementor-widget elementor-widget-heading\" data-id=\"1406e41\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/eg427.com\/EG-427-Receives-U-S--FDA-Fast-Track-Designation-for-EG110A-DNA-Medicine-in-Neurogenic-Bladder-Patients.html\" target=\"_blank\">Fast Track: https:\/\/eg427.com\/EG-427-Receives-U-S--FDA-Fast-Track-Designation-for-EG110A-DNA-Medicine-in-Neurogenic-Bladder-Patients.html<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9183fdc e-flex e-con-boxed e-con e-parent\" data-id=\"9183fdc\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d8da45e e-con-full e-flex e-con e-child\" data-id=\"d8da45e\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0c5e97c elementor-widget elementor-widget-heading\" data-id=\"0c5e97c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">DO YOU WANT TO KNOW MORE?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ab2242f e-flex e-con-boxed e-con e-child\" data-id=\"ab2242f\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4ef0cfd elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"4ef0cfd\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/10\/Capture-decran-2025-10-27-155313.png\" title=\"Capture d&#8217;\u00e9cran 2025-10-27 155313\" alt=\"Capture d&#039;\u00e9cran 2025-10-27 155313\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d327606 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"d327606\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Don&#8217;t miss the Innovations for Cell and Gene Therapies &#8220;ICGT&#8221;, organized by MabDesign, which will take place on May<strong> 27 and 28, 2025 in Sanofi Campus Gentilly, France<\/strong>.<\/p><p><i>More Information <a href=\"https:\/\/icgtcongress.com\/\">Here <\/a><\/i><i>or <a href=\"http:\/\/laure.delhon@mabdesign.fr\" target=\"_blank\" rel=\"noopener\">contact us<\/a> for more information !<\/i><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-73e803d elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"73e803d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>MabDesign has acquired and cultivated expertise in all areas associated with biomedicines and biomanufacturing. <a href=\"https:\/\/mabdesign.fr\/en\/the-team\/\">Our team<\/a> is at your disposal to support you in all your projects related to the biotherapies sector, and in particular cell-based therapies. Feel free to explore <a href=\"https:\/\/mabdesign.fr\/en\/our-consulting-offer-biomedicaments-bioproduction\/\">our range of services<\/a>, <a href=\"https:\/\/mabdesign-formation.fr\/\">training courses<\/a> and <a href=\"https:\/\/mabdesign.fr\/en\/our-events\/\">events<\/a> if you&#8217;d like to find out more!<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f12e48 elementor-align-center elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"0f12e48\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"mailto:services@mabdesign.fr?subject=Offre%20de%20services%20\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contact us<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>The Experts Corner &#8211; Discover our discussion with Samuel Salot of EG427 on Gene Therapies<\/p>\n","protected":false},"author":1,"featured_media":36304,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88,196],"tags":[440,442],"class_list":["post-36458","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bio-hub-en","category-interview-en","tag-genetherapies","tag-therapies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - 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