{"id":29626,"date":"2025-02-26T14:48:59","date_gmt":"2025-02-26T13:48:59","guid":{"rendered":"https:\/\/mabdesign.fr\/?p=29626"},"modified":"2025-02-26T16:07:06","modified_gmt":"2025-02-26T15:07:06","slug":"antibody-oligonucleotides-conjugates","status":"publish","type":"post","link":"https:\/\/mabdesign.fr\/en\/antibody-oligonucleotides-conjugates\/","title":{"rendered":"Antibody-oligonucleotides conjugates"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"29626\" class=\"elementor elementor-29626 elementor-29616\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7fc1a69 e-flex e-con-boxed e-con e-parent\" data-id=\"7fc1a69\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7a0ec25 elementor-widget elementor-widget-text-editor\" data-id=\"7a0ec25\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Each month, MabDesign&#8217;s market analyses give you an overview of market dynamics and projects in development for a given indication or technology, to help you better understand the constantly evolving market for biomedicines and biomanufacturing. This month, an overview of antibody-oligonucleotide conjugate (AOC) projects currently in development.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ce4a3b7 e-flex e-con-boxed e-con e-parent\" data-id=\"ce4a3b7\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aa7126d elementor-widget elementor-widget-text-editor\" data-id=\"aa7126d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The emergence of <a href=\"https:\/\/mabdesign.fr\/en\/antibody-drug-conjugates\/\">antibody-drug conjugates, ADCs,<\/a> marked a major advance in combining chemotherapy with <a href=\"https:\/\/mabdesign.fr\/en\/monoclonal-antibodies-mabs-stars-therapeutic-proteins\/\">monoclonal antibodies<\/a> to create a powerful immunotherapeutic tool. Their precision and efficacy make them an essential pillar in the development of cancer treatments.<\/p><p>In parallel, nucleic acid-based therapies have attracted attention for <b>their ability to modulate cellular functions at the genetic level using nucleotide sequence<\/b>s. These therapies can produce highly targeted and long-lasting therapeutic effects for hereditary and acquired diseases, such as genetic disorders, cancers, viral infections and neurological conditions.<\/p><p>Building on the success of ADCs, <b>antibody-oligonucleotide conjugates (AOCs)<\/b> have emerged as a new fusion, combining the precision of nucleic acids with the targeted delivery capability of antibodies.<\/p><p>Several pharmaceutical companies are conducting clinical trials on AOC drugs, including Avidity, which is developing the first AOC to enter the clinic, reaching phase III in May 2024.\u00a0<span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1rem;\">Despite these advances, research into AOCs is still in its infancy, with <\/span><b style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: 1rem;\">46 AOCs in development <\/b><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1rem;\">in the pipeline. Of these, 34.8% are antisense oligonucleotides (ASOs) and 32.6% are RNA interference (RNAi).<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6ce8628 e-con-full e-flex e-con e-parent\" data-id=\"6ce8628\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div class=\"elementor-element elementor-element-d77a2e4 e-con-full e-flex e-con e-child\" data-id=\"d77a2e4\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b2fbfd9 elementor-widget elementor-widget-heading\" data-id=\"b2fbfd9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Oligonucleotide types<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ac3e103 elementor-widget__width-initial elementor-widget elementor-widget-jet-pie-chart\" data-id=\"ac3e103\" data-element_type=\"widget\" data-widget_type=\"jet-pie-chart.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-jet-pie-chart jet-elements\"><div class=\"jet-pie-chart-title-container\"><h5 class=\"jet-pie-chart-title\"><\/h5><\/div>\n\t\t<div class=\"jet-pie-chart-container\" data-chart=\"{&quot;datasets&quot;:[{&quot;data&quot;:[6.5,34.8,32.6,26.1],&quot;backgroundColor&quot;:[&quot;#006272&quot;,&quot;#6BA539&quot;,&quot;#A4D233&quot;,&quot;#D2D755&quot;],&quot;borderWidth&quot;:1,&quot;borderColor&quot;:&quot;#ffffff&quot;,&quot;hoverBorderColor&quot;:&quot;#ffffff&quot;}],&quot;labels&quot;:[&quot;Aptamer&quot;,&quot;Antisense oligonucleotides &quot;,&quot;RNAi oligonucleotides&quot;,&quot;Undefined oligonucleotides&quot;]}\" data-options=\"{&quot;animation&quot;:{&quot;duration&quot;:1000,&quot;easing&quot;:&quot;easeOutQuart&quot;,&quot;animateScale&quot;:false},&quot;legend&quot;:{&quot;display&quot;:true,&quot;position&quot;:&quot;right&quot;,&quot;reverse&quot;:false,&quot;align&quot;:&quot;center&quot;},&quot;tooltips&quot;:{&quot;enabled&quot;:true}}\" data-tooltip=\"%\">\n\t\t\t<canvas class=\"jet-pie-chart\" role=\"img\"><\/canvas>\n\t\t<\/div>\n\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-036c883 e-con-full e-flex e-con e-child\" data-id=\"036c883\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-489c006 elementor-widget elementor-widget-text-editor\" data-id=\"489c006\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Number of AOCs in the pipeline<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-210597f elementor-widget__width-initial elementor-widget elementor-widget-counter\" data-id=\"210597f\" data-element_type=\"widget\" data-widget_type=\"counter.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-counter\">\n\t\t\t<div class=\"elementor-counter-title\">unique molecules<\/div>\t\t\t<div class=\"elementor-counter-number-wrapper\">\n\t\t\t\t<span class=\"elementor-counter-number-prefix\"><\/span>\n\t\t\t\t<span class=\"elementor-counter-number\" data-duration=\"2000\" data-to-value=\"46\" data-from-value=\"0\" data-delimiter=\",\">0<\/span>\n\t\t\t\t<span class=\"elementor-counter-number-suffix\"><\/span>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-663c437 elementor-widget elementor-widget-text-editor\" data-id=\"663c437\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Key players<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9646065 elementor-widget elementor-widget-image\" data-id=\"9646065\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"174\" src=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/02\/Capture-decran-2025-02-26-154125.png\" class=\"attachment-large size-large wp-image-29669\" alt=\"AOC, conjug\u00e9s anticorps oligonucl\u00e9otides\" srcset=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/02\/Capture-decran-2025-02-26-154125.png 820w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/02\/Capture-decran-2025-02-26-154125-300x65.png 300w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/02\/Capture-decran-2025-02-26-154125-768x167.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1083794 e-flex e-con-boxed e-con e-parent\" data-id=\"1083794\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9aa05e7 elementor-widget elementor-widget-text-editor\" data-id=\"9aa05e7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The antibody-oligonucleotide conjugate (AOC) industry is experiencing rapid momentum, as evidenced by recent partnerships between biotechs such as Avidity Biosciences and major pharmaceutical companies such as Bristol Myers Squibb and Eli Lilly.<\/p><ul><li>In 2019,<strong> Eli Lilly entered into a licensing and collaboration agreement with Avidity Biosciences<\/strong>, investing $35 million to develop new drugs based on antibody-oligonucleotide conjugates in immunology and other indications.<\/li><li><strong>Avidity announced a collaboration with Bristol Myers Squibb<\/strong> in 2023, with an initial investment of $100 million to develop five cardiovascular targets using Avidity&#8217;s AOC technology.<\/li><li>In October 2022, <strong>Sanofi and MiRecule announced a strategic collaboration<\/strong> and exclusive licensing agreement to develop and commercialise an antibody-RNA conjugate (ARC) for the treatment of facioscapulohumeral muscular dystrophy (FSHD).<\/li><\/ul><p>\u00a0<\/p><p>These collaborations illustrate the growing interest of major pharmaceutical companies in AOCs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d9d06cd e-flex e-con-boxed e-con e-parent\" data-id=\"d9d06cd\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7139c70 elementor-widget elementor-widget-jet-table\" data-id=\"7139c70\" data-element_type=\"widget\" data-widget_type=\"jet-table.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-jet-table jet-elements\">\n\t\t<div class=\"jet-table-wrapper\">\n\t\t\t<table class=\"jet-table jet-table--fa5-compat\">\n\t\t\t\t<thead class=\"jet-table__head\"><tr class=\"jet-table__head-row\"><th class=\"jet-table__cell elementor-repeater-item-4ae077a jet-table__head-cell\" scope=\"col\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">Acquirers<\/div><\/div><\/div><\/th><th class=\"jet-table__cell elementor-repeater-item-e053edb jet-table__head-cell\" scope=\"col\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">Issuer<\/div><\/div><\/div><\/th><th class=\"jet-table__cell elementor-repeater-item-84e8be5 jet-table__head-cell\" scope=\"col\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">Deal type<\/div><\/div><\/div><\/th><th class=\"jet-table__cell elementor-repeater-item-55bcb63 jet-table__head-cell\" scope=\"col\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">Value (US$m)<\/div><\/div><\/div><\/th><\/tr><\/thead>\n\t\t\t\t\t\t\t\t<tbody class=\"jet-table__body\"><tr class=\"jet-table__body-row elementor-repeater-item-4a60a25\"><td class=\"jet-table__cell elementor-repeater-item-c116c81 jet-table__body-cell\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">BMS<\/div><\/div><\/div><\/td><td class=\"jet-table__cell elementor-repeater-item-947c343 jet-table__body-cell\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">Avidity Biosciences<\/div><\/div><\/div><\/td><td class=\"jet-table__cell elementor-repeater-item-3a2f14d jet-table__body-cell\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">Licensing agreement<\/div><\/div><\/div><\/td><td class=\"jet-table__cell elementor-repeater-item-4b4a761 jet-table__body-cell\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">2.300<\/div><\/div><\/div><\/td><\/tr><tr class=\"jet-table__body-row elementor-repeater-item-f9f37dc\"><td class=\"jet-table__cell elementor-repeater-item-d0a571c jet-table__body-cell\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">Eli Lilly<\/div><\/div><\/div><\/td><td class=\"jet-table__cell elementor-repeater-item-daae613 jet-table__body-cell\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">Avidity Biosciences<\/div><\/div><\/div><\/td><td class=\"jet-table__cell elementor-repeater-item-af4e251 jet-table__body-cell\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">Licensing agreement<\/div><\/div><\/div><\/td><td class=\"jet-table__cell elementor-repeater-item-d4185ce jet-table__body-cell\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">440<\/div><\/div><\/div><\/td><\/tr><tr class=\"jet-table__body-row elementor-repeater-item-55ea945\"><td class=\"jet-table__cell elementor-repeater-item-0c74e54 jet-table__body-cell\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">Sanofi<\/div><\/div><\/div><\/td><td class=\"jet-table__cell elementor-repeater-item-cad7aa2 jet-table__body-cell\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">MiRecule<\/div><\/div><\/div><\/td><td class=\"jet-table__cell elementor-repeater-item-86c4276 jet-table__body-cell\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">Licensing agreement<\/div><\/div><\/div><\/td><td class=\"jet-table__cell elementor-repeater-item-752f3d5 jet-table__body-cell\"><div class=\"jet-table__cell-inner\"><div class=\"jet-table__cell-content\"><div class=\"jet-table__cell-text\">400<\/div><\/div><\/div><\/td><\/tr><\/tbody>\n\t\t\t<\/table>\n\t\t<\/div>\n\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d3ba93e e-flex e-con-boxed e-con e-parent\" data-id=\"d3ba93e\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c173825 elementor-widget elementor-widget-text-editor\" data-id=\"c173825\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The <strong>therapeutic areas targeted<\/strong> by the antibody-oligonucleotide conjugates in the pipeline are relatively varied, with a predominance in oncology, but also for pathologies affecting muscles and genetic diseases.<\/p><p>In terms of the progress of these projects, more than half are in the non-clinical phases of development. Only <strong>6 AOCs are currently in clinical phase.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7d7dbf2 elementor-widget elementor-widget-heading\" data-id=\"7d7dbf2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Development phases and therapeutic areas <\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a0263f3 e-flex e-con-boxed e-con e-parent\" data-id=\"a0263f3\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-10acf77 e-con-full e-flex e-con e-child\" data-id=\"10acf77\" data-element_type=\"container\" 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data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fe1af31 elementor-widget elementor-widget-heading\" data-id=\"fe1af31\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Download our infography<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67dfac7 elementor-widget elementor-widget-heading\" data-id=\"67dfac7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">antibody-oligonucleotide conjugates (2025)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7dbe063 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"7dbe063\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"768\" height=\"1024\" src=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/02\/Antibody-Oligonucleotide-Conjugates-February-768x1024.png\" class=\"attachment-large size-large wp-image-29619\" alt=\"conjugu\u00e9s anticorps-oligonucl\u00e9otides, antibody oligonucleotides conjugates\" srcset=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/02\/Antibody-Oligonucleotide-Conjugates-February-768x1024.png 768w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/02\/Antibody-Oligonucleotide-Conjugates-February-225x300.png 225w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/02\/Antibody-Oligonucleotide-Conjugates-February-1152x1536.png 1152w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2025\/02\/Antibody-Oligonucleotide-Conjugates-February.png 1500w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b415cb6 elementor-widget__width-initial elementor-align-center elementor-widget elementor-widget-jet-download-button\" data-id=\"b415cb6\" data-element_type=\"widget\" data-widget_type=\"jet-download-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-jet-download-button jet-elements\"><a class=\"elementor-button elementor-size-md jet-download jet-download-icon-position-left\" data-e-disable-page-transition=\"true\" href=\"https:\/\/mabdesign.fr\/en\/?jet_download=7adcd27c4220660b43f70a02d12f073873136b2c\" ><span class=\"jet-download__icon jet-download-icon-left jet-elements-icon\"><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-file-download\" viewBox=\"0 0 384 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M224 136V0H24C10.7 0 0 10.7 0 24v464c0 13.3 10.7 24 24 24h336c13.3 0 24-10.7 24-24V160H248c-13.2 0-24-10.8-24-24zm76.45 211.36l-96.42 95.7c-6.65 6.61-17.39 6.61-24.04 0l-96.42-95.7C73.42 337.29 80.54 320 94.82 320H160v-80c0-8.84 7.16-16 16-16h32c8.84 0 16 7.16 16 16v80h65.18c14.28 0 21.4 17.29 11.27 27.36zM377 105L279.1 7c-4.5-4.5-10.6-7-17-7H256v128h128v-6.1c0-6.3-2.5-12.4-7-16.9z\"><\/path><\/svg><\/span><span class=\"jet-download__text\"><span class=\"jet-download__label\">Download in .pdf<\/span><span class=\"jet-download__file-name\"><\/span><small class=\"jet-download__sub-label\"><\/small><\/span><\/a>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5b2916f e-con-full e-flex e-con e-child\" data-id=\"5b2916f\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8e2e2c5 elementor-widget elementor-widget-heading\" data-id=\"8e2e2c5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Want to know more ? <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16112cf3 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"16112cf3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: justify;\">MabDesign has acquired and cultivated expertise in all market segments associated with biomedicines and biomanufacturing. <a href=\"https:\/\/mabdesign.fr\/en\/the-team\/\">Our team<\/a> of consultants is available to support you in all your projects related to the biotherapeutics sector. Please feel free to explore <a href=\"https:\/\/mabdesign.fr\/en\/our-consulting-offer-biomedicaments-bioproduction\/\">our range of services<\/a>, including our <a href=\"https:\/\/mabdesign.fr\/en\/market-analyses\/\">marketing and strategic analyses<\/a>, if you&#8217;d like to find out more!<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1d5b9421 elementor-align-center elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"1d5b9421\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"mailto:services@mabdesign.fr?subject=Offre%20de%20services%20\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contact us<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1483b5 elementor-widget elementor-widget-text-editor\" data-id=\"e1483b5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Sources : MabDesign &amp; GlobalData<\/p><p><span style=\"text-align: var(--text-align); color: var( --e-global-color-text );\">Date &#8211; January 2025<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Each month, MabDesign&#8217;s market analyses give you an overview of market dynamics and projects in development for a given indication or technology, to help you better understand the constantly evolving market for biomedicines and biomanufacturing. This month, an overview of antibody-oligonucleotide conjugate (AOC) projects currently in development.<\/p>\n","protected":false},"author":4,"featured_media":29619,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88,119],"tags":[116,91,98,141,255],"class_list":["post-29626","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bio-hub-en","category-market-analysis-en","tag-advanced-therapy-medicinal-products","tag-atmp","tag-innovation-en","tag-market","tag-therapeutic-antibodies-and-proteins"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Antibody-oligonucleotides conjugates - MabDesign<\/title>\n<meta name=\"description\" content=\"Each month, MabDesign&#039;s market analyses give you an overview of market dynamics and projects in development for a given indication or technology, to help you better understand the constantly evolving market for biomedicines and biomanufacturing. 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