{"id":28002,"date":"2025-01-21T09:37:59","date_gmt":"2025-01-21T08:37:59","guid":{"rendered":"https:\/\/mabdesign.fr\/?p=28002"},"modified":"2025-03-27T10:45:39","modified_gmt":"2025-03-27T09:45:39","slug":"expertscorner_cell_therapy","status":"publish","type":"post","link":"https:\/\/mabdesign.fr\/en\/expertscorner_cell_therapy\/","title":{"rendered":"Experts&#8217; corner : Cell therapies"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"28002\" class=\"elementor elementor-28002 elementor-26503\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bb69397 e-flex e-con-boxed e-con e-parent\" data-id=\"bb69397\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0f10725 e-con-full e-flex e-con e-child\" data-id=\"0f10725\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6ba549e elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"6ba549e\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"948\" src=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2024\/12\/Experts-Corner-1-864x1024.png\" class=\"attachment-large size-large wp-image-26511\" alt=\"\" srcset=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2024\/12\/Experts-Corner-1-864x1024.png 864w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2024\/12\/Experts-Corner-1-253x300.png 253w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2024\/12\/Experts-Corner-1-768x910.png 768w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2024\/12\/Experts-Corner-1.png 1036w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1285290 e-con-full e-flex e-con e-child\" data-id=\"1285290\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[],&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c1f29b9 elementor-widget elementor-widget-heading\" data-id=\"c1f29b9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Cell therapies<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-185c31b e-con-full e-flex e-con e-child\" data-id=\"185c31b\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ff9880c elementor-widget elementor-widget-heading\" data-id=\"ff9880c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Sophie derenne<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-95226ce elementor-widget elementor-widget-heading\" data-id=\"95226ce\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Head of Market Analysis and Development at EFS<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbd1a3a e-con-full e-flex e-con e-child\" data-id=\"bbd1a3a\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-431b3cd elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"431b3cd\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-quote-left\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M464 256h-80v-64c0-35.3 28.7-64 64-64h8c13.3 0 24-10.7 24-24V56c0-13.3-10.7-24-24-24h-8c-88.4 0-160 71.6-160 160v240c0 26.5 21.5 48 48 48h128c26.5 0 48-21.5 48-48V304c0-26.5-21.5-48-48-48zm-288 0H96v-64c0-35.3 28.7-64 64-64h8c13.3 0 24-10.7 24-24V56c0-13.3-10.7-24-24-24h-8C71.6 32 0 103.6 0 192v240c0 26.5 21.5 48 48 48h128c26.5 0 48-21.5 48-48V304c0-26.5-21.5-48-48-48z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3dd7198 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"3dd7198\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>&#8220;Cell therapy represents a revolution on par with the advent of antibiotics.&#8221;<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b4eba7b elementor-widget__width-initial elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"b4eba7b\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-quote-right\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M464 32H336c-26.5 0-48 21.5-48 48v128c0 26.5 21.5 48 48 48h80v64c0 35.3-28.7 64-64 64h-8c-13.3 0-24 10.7-24 24v48c0 13.3 10.7 24 24 24h8c88.4 0 160-71.6 160-160V80c0-26.5-21.5-48-48-48zm-288 0H48C21.5 32 0 53.5 0 80v128c0 26.5 21.5 48 48 48h80v64c0 35.3-28.7 64-64 64h-8c-13.3 0-24 10.7-24 24v48c0 13.3 10.7 24 24 24h8c88.4 0 160-71.6 160-160V80c0-26.5-21.5-48-48-48z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-34244d1 e-flex e-con-boxed e-con e-parent\" data-id=\"34244d1\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e6b8003 e-con-full e-flex e-con e-child\" data-id=\"e6b8003\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e2e2618 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"e2e2618\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"438\" height=\"438\" src=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2024\/12\/logo-EFS.png\" class=\"attachment-large size-large wp-image-26549\" alt=\"EFS, \u00e9tablissement fran\u00e7ais du sang\" srcset=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2024\/12\/logo-EFS.png 438w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2024\/12\/logo-EFS-300x300.png 300w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2024\/12\/logo-EFS-150x150.png 150w\" sizes=\"(max-width: 438px) 100vw, 438px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7ffca97 e-con-full e-flex e-con e-child\" data-id=\"7ffca97\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-256af04 elementor-widget elementor-widget-text-editor\" data-id=\"256af04\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The <a href=\"https:\/\/dondesang.efs.sante.fr\/\">Etablissement Fran\u00e7ais du Sang<\/a>, or EFS, is a public body with a monopoly on the collection of blood from blood donations. The EFS also has a number of other activities relating to the development and production of cell-based therapies. For several years, it has been involved in conventional cell therapy, i.e. haematopoietic stem cell transplants for haematology patients. Gradually, the EFS has extended its bioproduction activities to new cell types, now recognised as advanced therapy medicinal products (ATMPs)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3aae58e e-flex e-con-boxed e-con e-parent\" data-id=\"3aae58e\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b96cbb4 elementor-widget elementor-widget-heading\" data-id=\"b96cbb4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Cell therapies at EFS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4e5f4fb e-flex e-con-boxed e-con e-parent\" data-id=\"4e5f4fb\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e402d66 elementor-widget elementor-widget-text-editor\" data-id=\"e402d66\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>How long has the EFS been working on cellular therapies?<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-028473c elementor-widget elementor-widget-text-editor\" data-id=\"028473c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The EFS was already working on the <strong>cell as a therapeutic tool<\/strong> long before the MTI status came into being, especially as we have research teams (usually joint, Inserm and others) working on the research and development of biotherapies, of which ATMPs are a part.<\/p><p>With the changes in regulations, the EFS has quite simply brought itself into line. <strong>EFS now has 4 pharmaceutical establishments<\/strong> in Nantes, Cr\u00e9teil, Besan\u00e7on and Grenoble. The Besan\u00e7on Innovation Platform (PIBT) was accredited following a call for proposals for an industrial integrator. The integrator offers researchers or biotech companies the opportunity to<strong> take charge of beta-testing or technological transposition of the bioproduction part of their cell therapy,<\/strong> including, for example, the transition to a closed circuit, scale-up, etc. The aim is to ensure that R&amp;D projects reach the first stages of clinical trials. The EFS will soon be celebrating its 25th anniversary as a single institution.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0fec223 e-flex e-con-boxed e-con e-parent\" data-id=\"0fec223\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2c0b365 elementor-widget elementor-widget-text-editor\" data-id=\"2c0b365\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>What does the Biology, Therapy and Diagnostics Department do?<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b242629 elementor-widget elementor-widget-text-editor\" data-id=\"b242629\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>This department manages cell therapy and bioproduction activities, the specialised analysis laboratory, reagent production and the provision of products, particularly for teaching and research. It is this last activity that will enable cells to be made available to research teams.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b41be0d e-flex e-con-boxed e-con e-parent\" data-id=\"b41be0d\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-81de370 elementor-widget elementor-widget-text-editor\" data-id=\"81de370\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Can you tell us about your role in this department?<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2460c79 e-flex e-con-boxed e-con e-parent\" data-id=\"2460c79\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e9eac3b elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"e9eac3b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>As head of the market analysis and development department, my job is to <strong>keep abreast of developments in our field<\/strong>: How and where is science evolving? What new medicines will revolutionise transfusion or cell therapy, for example? Who are the innovators in this field?<\/p><p>This enables us to propose new directions, for example in the field of CAR-T cells, that have revolutionised immunotherapy. I&#8217;m also helping to raise the profile of our services. It&#8217;s true that our expertise is recognised by our customers, but many people, including those in the biomanufacturing sector, think that the EFS only deals with blood donations. We have a <strong>very broad range of activities<\/strong>, and it&#8217;s important to raise awareness of these different areas. The aim is to <strong>make our structures and expertise available<\/strong> to as many professionals as possible.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-587cae2 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"587cae2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u2018Many people, including those in the biomanufacturing sector, think that the EFS only deals with blood donations\u2019.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d50c4c4 e-flex e-con-boxed e-con e-parent\" data-id=\"d50c4c4\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ba90dca elementor-widget elementor-widget-heading\" data-id=\"ba90dca\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Innovations, challenges and prospects for cellular therapies <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ad30eb0 e-flex e-con-boxed e-con e-parent\" data-id=\"ad30eb0\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-505aec2 elementor-widget elementor-widget-text-editor\" data-id=\"505aec2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>How has the field of cell therapy evolved during your career?<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0e4dd0a e-flex e-con-boxed e-con e-parent\" data-id=\"0e4dd0a\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec2c1a elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"8ec2c1a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u2018CAR-Ts are no longer fashionable in 2024, they have been replaced by ADCs\u2019<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5636996 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"5636996\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>I find this development rather strange. In a way, things are speeding up. You could say that cell therapy began with haematopoietic stem cells and then mesenchymal stem cells. At the time, there were already clinical trials with immunotherapies, notably in Besan\u00e7on, but these remained more or less confidential. It was <strong>CAR-Ts that really brought to light the potential of cellular therapies<\/strong>, contributing to the craze for treatments based on genetically modified cells and viral vectors. Today, we have <strong>the impression that this enthusiasm is waning,<\/strong> particularly among investors: CAR-Ts are no longer \u2018fashionable\u2019 in 2024, replaced by ADCs. In my opinion, we are in a cycle that lacks scientific logic. The CAR-T field has benefited from massive, and probably excessive, investment at a certain point, without sufficient hindsight. However, like any emerging field, <strong>cell therapy is still in its infancy<\/strong>. As I&#8217;ve always said, <strong>cell therapy is the equivalent of antibiotics in terms of revolution, but it takes time.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-74aae84 e-flex e-con-boxed e-con e-parent\" data-id=\"74aae84\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-98ae598 elementor-widget elementor-widget-text-editor\" data-id=\"98ae598\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>To date, more than forty cell therapies have been brought to market, including around ten based on mesenchymal stem cells. The pipeline of products in development is quite substantial in terms of\u00a0 number of candidates: what is your opinion on this dynamic?<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-35a90cf elementor-widget elementor-widget-text-editor\" data-id=\"35a90cf\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Mesenchymal cells<\/strong> have been manipulated for several years. With the benefit of hindsight, we now have <strong>better control over their development<\/strong> and marketing. On the other hand, new types of cell therapy are more complex, but potentially more effective and, above all, more targeted. This means that we should certainly find it easier to reach Phases I\/II, but <strong>we can expect a gap before moving on to Phase III<\/strong>, with potential funding problems.<\/p><p>I have also witnessed a positive evolution in the professionalism of project leaders. 10-15 years ago, they arrived with little knowledge of the cell therapy development value chain. Today, on the other hand, they have a<strong> better grasp of the field<\/strong>, and in particular of the prerequisites for moving into clinical trials. As a result, I think this will speed up the arrival of new cell therapies that can be approved. Of course, we can&#8217;t expect all the products in the pipeline to reach the market because of the attrition rates that apply to each phase.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d017512 e-flex e-con-boxed e-con e-parent\" data-id=\"d017512\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ca5ab23 elementor-widget elementor-widget-text-editor\" data-id=\"ca5ab23\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>What are the latest tools and innovative technologies in the sector?<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-09f6ba3 e-flex e-con-boxed e-con e-parent\" data-id=\"09f6ba3\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6fbca2d elementor-widget elementor-widget-text-editor\" data-id=\"6fbca2d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>I&#8217;d like to mention <strong>CRISPR\/Cas9 and other types of DNA scissors,<\/strong> revolutionary technologies that provide greater control over gene modifications of therapeutic targets. They will undoubtedly lead to new curative solutions for patients who have reached a therapeutic impasse. At the same time, we are seeing the <strong>emergence of innovative technologies for the production<\/strong> of these therapies. A few years ago, there were no automated machines suitable for producing cell therapies, compared with the equipment used to produce antibodies in CHO cells. Then came the <strong>first small machines for producing autologous CAR-Ts:<\/strong> this production model is likely to continue, given the development of personalised medicine. However, this autologous model<strong> will not be economically viable in the long term<\/strong> to treat a growing number of patients unless the cost is reduced, for example by optimising quality control processes (representing 30-40% of the price). We could also move towards allogeneic models, but we are still lacking some technological innovations for this.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-59c4560 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"59c4560\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u2018The production of autologous CAR-T will not be viable on a large scale unless costs are reduced\u2019.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9cae32b e-flex e-con-boxed e-con e-parent\" data-id=\"9cae32b\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ebb93bb elementor-widget elementor-widget-text-editor\" data-id=\"ebb93bb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Technological innovations are providing solutions to optimise the development of cell therapies, and also to remove barriers throughout the value chain. In your opinion, what are the main challenges to be resolved?<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3fe0c98 e-flex e-con-boxed e-con e-parent\" data-id=\"3fe0c98\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-448be96 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"448be96\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u2018French academic research has a fine ecosystem in cellular therapies, but it has too few links with industry\u2019.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cab5050 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"cab5050\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Each stage of development, from R&amp;D to biomanufacturing, has its own barriers. In France, on the R&amp;D side, I think we have a <strong>good ecosystem of academic teams<\/strong> developing innovative products, and strong financial support from the government. However, one of the pitfalls I see at national level is that<strong> this research is not systematically linked to industry.<\/strong> We end up with a model where most of the time the researcher has to set up a start-up to take his cell therapy project forward, with all the difficulties associated with entrepreneurship. The associated constraints, including the <strong>enormous difficulty of finding private funding<\/strong>, mean that, unfortunately, many start-ups fail despite promising and innovative projects.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f4d5861 e-flex e-con-boxed e-con e-parent\" data-id=\"f4d5861\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3bbbce7 elementor-widget elementor-widget-text-editor\" data-id=\"3bbbce7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Talking of private funding, why is it so difficult for cell therapy developers to convince investors?<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6bbe636 elementor-widget elementor-widget-text-editor\" data-id=\"6bbe636\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>First of all, <strong>investors need to be educated about development times<\/strong> in this field. A number of reports have shown that platforms such as Uber, for example, took around ten years to become successful. The same applies to biomedical products, which take a long time to come to fruition. We need to educate investors about the time it takes to develop a biotherapy, from non-clinical phases to clinical trials, and about the potential of cell therapy, without deluding them about <strong>the risks and the attrition rate<\/strong> in this field.<\/p><p>Speaking of risks, it&#8217;s important not to overreact to them. Take, for example, the FDA&#8217;s recent warnings, quite rightly, about the appearance of secondary tumours after CAR-T injections. Here, it is <strong>important to consider the benefit\/risk balance<\/strong> for the patient, who is often at a therapeutic impasse, without forgetting that this type of risk is also present for other types of oncology treatment, such as conventional chemotherapy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-596bfa8 e-flex e-con-boxed e-con e-parent\" data-id=\"596bfa8\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3699c12 elementor-widget elementor-widget-text-editor\" data-id=\"3699c12\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>This year, MabDesign launched the first edition of its annual conference on cell and gene therapy, the <a href=\"https:\/\/icgtcongress.com\/\">ICGT (Innovations for Cell &amp; Gene Therapies)<\/a>, in response to the need for industry and academia to meet and gain greater visibility. You were a member of the scientific committee for this first event. What is your feedback from the conference?\u00a0<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f45976 e-flex e-con-boxed e-con e-parent\" data-id=\"7f45976\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ae9cc78 elementor-widget elementor-widget-text-editor\" data-id=\"ae9cc78\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>For a first edition, it was <strong>a great success.<\/strong> The presentations were of a <strong>very high standard<\/strong> and there were a lot of people in attendance. Clearly, we almost regretted that it only lasted one day, but frankly, it was a great success. We can&#8217;t wait for the next edition!<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c7d7e09 e-flex e-con-boxed e-con e-parent\" data-id=\"c7d7e09\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef3f597 elementor-widget elementor-widget-heading\" data-id=\"ef3f597\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Sophie Derenne, interviewed by the MabDesign team - December 2024<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9183fdc e-flex e-con-boxed e-con e-parent\" data-id=\"9183fdc\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d8da45e e-con-full e-flex e-con e-child\" data-id=\"d8da45e\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0c5e97c elementor-widget elementor-widget-heading\" data-id=\"0c5e97c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Vous souhaitez en savoir plus ? <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ab2242f e-flex e-con-boxed e-con e-child\" data-id=\"ab2242f\" data-element_type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4ef0cfd elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"4ef0cfd\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"734\" height=\"390\" src=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2024\/04\/Co-organization.png\" class=\"attachment-large size-large wp-image-23074\" alt=\"ICGT, Cell &amp; Gene therapy congress, MabDesign\" srcset=\"https:\/\/mabdesign.fr\/wp-content\/uploads\/2024\/04\/Co-organization.png 734w, https:\/\/mabdesign.fr\/wp-content\/uploads\/2024\/04\/Co-organization-300x159.png 300w\" sizes=\"(max-width: 734px) 100vw, 734px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d327606 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"d327606\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: justify;\"><i>Don&#8217;t miss the second edition of the congress\u00a0 <\/i><em><a style=\"font-family: S\u00f6hne, ui-sans-serif, system-ui, -apple-system, 'Segoe UI', Roboto, Ubuntu, Cantarell, 'Noto Sans', sans-serif, 'Helvetica Neue', Arial, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji'; font-size: 1rem; white-space-collapse: preserve; text-align: var(--text-align); font-weight: var( --e-global-typography-text-font-weight );\" href=\"https:\/\/icgtcongress.com\/\" target=\"_blank\" rel=\"noopener\">Innovations for Cell and Gene Therapies (ICGT)<\/a><\/em><span style=\"color: #0d0d0d; font-family: S\u00f6hne, ui-sans-serif, system-ui, -apple-system, Segoe UI, Roboto, Ubuntu, Cantarell, Noto Sans, sans-serif, Helvetica Neue, Arial, Apple Color Emoji, Segoe UI Emoji, Segoe UI Symbol, Noto Color Emoji;\"><span style=\"white-space-collapse: preserve;\"><em> organised by MabDesign<\/em> <i>in collaboration with the <a href=\"https:\/\/www.sftcg.fr\/\">SFTCG<\/a>, that will take place <strong>in Paris on May 22nd &amp; 23rd, 2025. <\/strong><\/i><\/span><\/span><\/p><p style=\"text-align: justify;\"><span style=\"color: #0d0d0d; font-family: S\u00f6hne, ui-sans-serif, system-ui, -apple-system, Segoe UI, Roboto, Ubuntu, Cantarell, Noto Sans, sans-serif, Helvetica Neue, Arial, Apple Color Emoji, Segoe UI Emoji, Segoe UI Symbol, Noto Color Emoji;\"><span style=\"white-space-collapse: preserve;\"><i>You can already <a href=\"https:\/\/icgtcongress.com\/register-b2b-access\/\">register <\/a><\/i><\/span><\/span><span style=\"color: #0d0d0d; font-family: S\u00f6hne, ui-sans-serif, system-ui, -apple-system, Segoe UI, Roboto, Ubuntu, Cantarell, Noto Sans, sans-serif, Helvetica Neue, Arial, Apple Color Emoji, Segoe UI Emoji, Segoe UI Symbol, Noto Color Emoji;\"><span style=\"white-space-collapse: preserve;\"><i>or <a href=\"mailto:laure.delhon@mabdesign.fr\">contact us<\/a> for more information !<\/i><\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-73e803d elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"73e803d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"MsoNormal\" style=\"text-align: justify;\">MabDesign has acquired and cultivated expertise in all areas associated with biomedicines and biomanufacturing. <a href=\"https:\/\/mabdesign.fr\/en\/the-team\/\">Our team<\/a> is at your disposal to support you in all your projects related to the biotherapies sector, and in particular cell-based therapies. Feel free to explore <a href=\"https:\/\/mabdesign.fr\/en\/our-consulting-offer-biomedicaments-bioproduction\/\">our range of services<\/a>, <a href=\"https:\/\/mabdesign-formation.fr\/\">training courses<\/a> and <a href=\"https:\/\/mabdesign.fr\/en\/our-events\/\">events<\/a> if you&#8217;d like to find out more!<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a5f4fc0 elementor-align-center elementor-widget__width-initial elementor-widget elementor-widget-button\" data-id=\"a5f4fc0\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"mailto:services@mabdesign.fr?subject=Offre%20de%20services%20\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contact us<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>The Experts Corner &#8211; Read our interview with Sophie Derenne from the EFS, on the cell therapy market, its challenges and prospects.<\/p>\n","protected":false},"author":4,"featured_media":29023,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88,196],"tags":[91,257],"class_list":["post-28002","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bio-hub-en","category-interview-en","tag-atmp","tag-cell-and-gene-therapy"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Experts&#039; corner : Cell therapies - MabDesign<\/title>\n<meta name=\"description\" content=\"The Experts Corner - Read our interview with Sophie Derenne from the EFS, on the cell therapy market, its challenges and prospects.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mabdesign.fr\/en\/expertscorner_cell_therapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Experts&#039; 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