{"id":16903,"date":"2017-08-08T07:07:29","date_gmt":"2017-08-08T05:07:29","guid":{"rendered":"http:\/\/mabdesign.fr\/nih-researchers-identify-genes-essential-for-immunotherapy\/"},"modified":"2024-12-16T16:17:51","modified_gmt":"2024-12-16T15:17:51","slug":"nih-researchers-identify-genes-essential-for-immunotherapy","status":"publish","type":"post","link":"https:\/\/mabdesign.fr\/en\/nih-researchers-identify-genes-essential-for-immunotherapy\/","title":{"rendered":"NIH Researchers Identify Genes Essential for Immunotherapy"},"content":{"rendered":"<p style=\"text-align: justify;\">August 7, 2017 &#8211; BioCentury<\/p>\n<p style=\"text-align: justify;\">In a <a class=\"\" href=\"https:\/\/www.nature.com\/nature\/journal\/vaop\/ncurrent\/full\/nature23477.html\">paper<\/a> published in <em>Nature<\/em>, researchers at NIH&#8217;s NCI and colleagues identified about 100 genes that may be tied to immunotherapy resistance in cancer cells.<\/p>\n<p>The researchers used a CRISPR-Cas9 (CRISPR-associated protein 9) loss-of-function screen in human melanoma cell lines targeting over 19,000 protein-encoding genes to test the impact of somatic mutations on T cell response. The authors sought to identify genes that have key roles in antigen presentation and interferon-gamma signaling, which affects T cell recognition of tumors.<\/p>\n<p>The assay resulted in the identification of about 100 genes that may be necessary for immunotherapy. Nicholas Restifo, who led the study, told BioCentury that \u201cdozens\u201d of those genes were previously unknown to play a role in T cell recognition of tumors. Restifo is a senior investigator at NCI&#8217;s Center for Cancer Research.<\/p>\n<p><strong><a href=\"https:\/\/www.biocentury.com\/bc-extra\/preclinical-news\/2017-08-07\/nih-researchers-identify-genes-essential-immunotherapy\" target=\"_blank\" rel=\"noopener\">Read more<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at NIH&#8217;s NCI and colleagues identified about 100 genes that may be tied to immunotherapy resistance in cancer cells.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[],"class_list":["post-16903","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NIH Researchers Identify Genes Essential for Immunotherapy - MabDesign<\/title>\n<meta name=\"description\" content=\"Researchers at NIH&#039;s NCI and colleagues identified about 100 genes that may be tied to immunotherapy resistance in cancer cells.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mabdesign.fr\/en\/nih-researchers-identify-genes-essential-for-immunotherapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NIH Researchers Identify Genes Essential for Immunotherapy - 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